Stem Cell-Based Regenerative Medicine Leads to a Paradigm Shift in Gynecological Treatment
Miracell Hosts the 38th CGP Academy With stem cell-based regenerative therapies garnering attention in the field of improving women’s health, Professor Lee Eun-sil of the Department of Obstetrics and Gynecology at Soonchunhyang University Seoul Hospitaldelivered a lecture on “Gynecological Applications of Stem Cells (CD34+) and BSCs” to obstetricians and gynecologists at the CGP Academy hosted by Miracell Co., Ltd. on the 20th of last month. Degeneration or damage to the reproductive organs, including the uterus, vagina, and vulva, is a common problem after menopause. Common examples include vaginal atrophy, endometrial damage, and decreased sexual function. Furthermore, degenerative changes in bladder tissue due to aging weaken pelvic floor muscles, leading to bladder sagging, decreased urinary function, and urinary incontinence.In her lecture, Professor Lee highlighted the potential of regenerative medicine approaches to address these issues. In his lecture, Professor Lee explained the mechanism of action, saying, “Stem cells are effective in regenerating damaged tissues and restoring function.CD34+ cells contain various growth factors and cytokines, including stem cells, which stimulate tissue regeneration, angiogenesis, cell migration, differentiation, and proliferation.In particular, they are rich in white blood cells, making them particularly effective in antibacterial action and immune regulation.” He continued, “He emphasized the potential benefits of stem cell utilization on the health of the female reproductive system, highlighting key areas where endometrial regeneration, enhanced receptivity, and increased clinical pregnancy rates are anticipated.” Professor Lee Eun-sil explained, “SMART M-CELL can manufacture CD34+ stem cells, which play a crucial role in angiogenesis.” “The CD34+ marker is primarily found in hematopoietic stem cells and vascular endothelial progenitor cells. When whole blood was treated with SMART M-CELL, CD34+ concentration increased by approximately 5-6 times,and growth factors such as VEGF and PDGF increased by 2-3 times compared to whole blood.” He continued, “CD34+ HSCs (blood stem cells) can differentiate into all blood cells, and CD34+ EPCs (vascular endothelial progenitor cells) are mobilized to damaged blood vessels,forming new blood vessels, repairing existing ones, and promoting tissue regeneration.”“In other words, CD34+ cells are the source cells that produce blood cells and blood vessels, and are involved in tissue regeneration, angiogenesis, and immune regulation, contributing to skin regeneration, immune response regulation, inflammation suppression, and tissue repair.” Professor Lee emphasized the effectiveness of regenerative medicine treatments, citing numerous clinical cases and research papers. “Clinical Evaluation of Autologous Platelet-Rich Plasma Injection in Postmenopausal Vulvovaginal Atrophy: A Pilot Study (2022)” After two PRP injections in 47 women with postmenopausal vulvar and vaginal atrophy,“significant improvements were observed in Vaginal Health Index (VHI) and Vulvar Symptom Questionnaire (VSQ) scores, and no major adverse effects were reported.” Professor Lee Eun-sil emphasized the treatment mechanism, saying, “CD34+ stem cell injection induces angiogenesis, improving blood flow within tissues. Endothelial regeneration and increased mucosal vascular density enhance oxygen and nutrient supply to tissues. Furthermore, the regenerative effect is promoted by the cytokines and growth factors secreted by stem cells.” He continued, “Stem cell (CD34+) injections are minimally invasive and highly safe because they utilize autologous material.” He added, “CD34+ stem cells promote tissue regeneration, enhance collagen production,stimulate new blood vessel formation, and reduce inflammation. They have potential therapeutic effects for a wide range of gynecological problems, including vaginal dryness, stress urinary incontinence, bladder pain syndrome, and improved sexual function.” At the academy, Dr. Kim Tae-ryun of Selfia Clinic performed stem cell treatment on PYAGAY KLYOSHA (73 years old, Russia), a foreign patient with degenerative bladder disease who complained of urinary incontinence and vaginal dryness. This non-surgical approach, incorporating cellular medicine to improve aging bladder function, helps alleviate symptoms. Domestic stem cell treatments are so popular overseas that they are even attracting medical tourism. Source: Edaily (https://www.edaily.co.kr/News/Read?newsId=03398086642328984&mediaCodeNo=257&OutLnkChk=Y)